5-chloro-1H-pyrazolo[3

Name	5-Chloro-1H-pyrazolo[3,4-c]pyridine
Synonyms	5-chloro-1H-pyrazolo[3 5-Chloro-1H-pyrazolo[3,4-... 5-CHLORO-1H-PYRAZOLO[3,4-C]PYRIDINE 5-Chloro-1H-pyrazolo[3,4-c]pyridine 1H-Pyrazolo[3,4-c]pyridine,5-chloro- 1H-pyrazolo[3,4-c]pyridine, 5-chloro-
CAS	76006-08-1
InChI	InChI=1/C6H4ClN3/c7-6-1-4-2-9-10-5(4)3-8-6/h1-3H,(H,9,10)

Molecular Formula	C6H4ClN3
Molar Mass	153.57
Density	1.531±0.06 g/cm3(Predicted)
Melting Point	184-185 °C
Boling Point	357.5±22.0 °C(Predicted)
Flash Point	201.2°C
Vapor Presure	5.6E-05mmHg at 25°C
pKa	9.74±0.40(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.72

Use	5-chloro-1H-pyrazolo [3,4-C] pyridine is used as a research compound.
application	5-chloro-1H-pyrazolo [3,4-C] pyridine is a pyrazolo aromatic heterocyclic compound, is an important organic synthesis intermediate, widely used in the preparation of pharmaceutical, pesticide and other compounds.
preparation	at room temperature, 2-chloro -5-fluoro -4-aldehyde pyridine (0.49mol,75.0g), methoxyamine hydrochloride (0.51mol, 42.6g) and potassium carbonate (0.59mol,81.5g) were respectively added to the reactor containing 1L tetrahydrofuran solution. After stirring at room temperature overnight, filter and concentrate the filtrate to obtain the residue. Add 85% by weight of hydrazine hydrate aqueous solution (1.47mol) drops to the residue and reflux overnight, and monitor the progress of the reaction with LC-MS until the end of the reaction. After evaporating the excess hydrazine, add 1L of water to the mixture, precipitate the precipitate, filter, wash the precipitate with water and dry to obtain gray powder. After dissolving gray powder with tetrahydrofuran, add 10mL of trifluoroacetic acid and reflux for 1 hour, concentrate the reaction mixture, wash with water and tert-butyl methyl ether for three times to obtain a light gray powder of pyrazolo heterocyclic compound (I. e. 5-chloro-1H-pyrazolo [3,4-C] pyridine) powder, the yield is 86%, and the purity is greater than 95%. 1H-NMR(CD3OD-d4,400MHz)δ:7.82(s,1H),8.15(s,1H), 8.80(s,1H).

Last Update：2024-04-09 19:05:03